Synergies

Some items will produce a unique effect when held at the same time. A light blue arrow will appear above players for a short duration to show that a special combo has been activated.

When viewing currently held items in the Ammonomicon, selecting an item in a synergy will also highlight the other items in the synergy.

Notes

• For any synergy that includes guns, any stat modifications granted by the synergy only apply to the guns in the synergy.

List of Synergies

Name	Items		Effect
	Blooper Heavy Boots		Blooper shoots faster and deals more damage; however, some shots are blank.
	Crestfaller Double Vision
	Excaliber RPG		Excaliber fires 3 projectiles in a cone when reloaded.
	Nail Gun H4mmer		50% more max ammo.
	Nail Gun Sunglasses		Nails are larger and cause bleeding.
	Starpew Pea Shooter		Pea Shooter gets bigger peas and increased damage.
	Lower Case r Rocket-Powered Bullets		Lower Case r spells "ROCKET", "BOOM", and "POW" when fired and rounds explode.
	A.W.P. Scope
	Particulator Laser Sight		Fires lasers
	Lower Case r Omega Bullets
	Snowballer Frost Bullets
	Relodestone Uranium Ammolet
	Starpew Trashcannon		Trashcannon becomes a recycling bin with higher damage and a larger magazine size.
	Any one of the following: Bumbullets Jar of Bees Bee Hive	Table Tech Blanks	A swarm of bees replaces enemy bullets when a table is flipped.
	AKEY-47 Shelleton Key		The AKEY-47 receives a damage boost and infinite ammo.
5 O'Clock Somewhere	Crestfaller Shotga Cola		Reloading will fire a Bottle Cap(?) that will stun enemies it hits.
Above the Law	Colt 1851 Table Tech Sight
Absent Minded	The Membrane Bouncy Bullets		The Membrane's shots bounce 4 times and become homing.
Ancient Aliens	Zorgun Alien Engine		Gives Zorgun 3 Final Shots, and gives Alien Engine occasional Zorgun bullets.
Assault and Battery	Shock Rifle	M16	When either is equiped, the player dual wields them both.
Arctic Warfare	A.W.P. Frost Bullets
Armored Corps	AC-15 Void Core Assault Rifle		Void Core Assault Rifle's shots become faster and deal more damage.
Bacon and Eggs	The Scrambler Pig		Increases the speed of the Scrambler's eggs by 50%.
Blank Generation	Elder Blank Blank Companion's Ring		Familiar changes appearance to be older, automatically fires a second blank after Elder Blank's blank duration ends
Careful Iteration	Any one of the following: Armor of Thorns Shotgun Full of Hate Nail Gun Eyepatch	Casey	Casey becomes spiked and fires a spread of 6 nails each time it is swung.
Cast Iron	Any one of the following:	File:Bundle of wands.png Bundle of wands Witch Pistol	Big Iron	Gives the Big iron transmogrification effects and replaces one bullet with a beam.
Chicken Arise	Any one of the following: Bundle of Wands Hexagun Staff of Firepower Witch Pistol	Magic Bullets	Increases the chance for the guns to transmogrify enemies.
Chief Master	Alien Sidearm Master Round II		The Alien Sidearm has a much larger magazine, and all but the last two bullets in its magazine are chargeable.
Clearer Guon Stone	Clear Guon Stone +1 Bullets		Unknown
Cold Ones	Frost Bullets Frost Ammolet
Contrail	Alien Engine Mutation
Diamond Weapon	Frost Bullets Omega Bullets
Finger on the Pulse	Pulse Cannon Heart Lunchbox
Get Equipped With -B-	Megahand	Mega Douser or Bubble Blaster	Reloading the Megahand with a full magazine switches to Bubble Lead mode, which behaves like the Bubble Blaster.
Get Equipped with -F-	Megahand Camera		Reloading the Megahand with a full magazine switches to Time Stopper mode, which fires a flash that stops time for a second and deals damage to all enemies on screen.
Gruber's Bane	Backup Gun Shadow Bullets		Backup Gun has a 100% chance of firing shadow bullets.
Guns and Deviltry	Grey Mauser Winchester Rifle		The guns fire a knife whenever reloading.
Hail, Satan!	Demon Head Pitchfork		The Demon Head gains piercing.
Husky	Dog Wolf		Spawns smaller versions of the Wolf and Dog that follow the player, other effects unknown.
Inconsistent Scale	Bee Hive Gungeon Ant		While Gungeon Ant is held, creates a beehive orbital that spawns bees.
Iron Stance	Any one of the following: Anvillain Big Iron Tangler Pulse Cannon Old Goldie Blunderbuss	Heavy Boots or Heavy Bullets	Increases the damage of the guns by 20% and decreases their shot speed by 25%.
It's Your Destiny	The Exotic Ice Breaker
Keep The Change	M16 Blank Companion's Ring
Lotus Bloom	Laser Lotus Rolling Eye		The Laser Lotus gains the appearance of a flower, and has a larger magazine.
Love/Hate	Shotgun Full of Hate Shotgun Full of Love		Dual wield the shotguns.
Mr.Shadow	Zorgun Shadow Bullets		Zorgun Shadow Bullets become the random explosives Zorgun fires as its last shot.
Noxin Cannon	Luxin Cannon Shadow Bullets		Luxin Cannon and its shots turn grey, other effects unknown.
Over Dose	Heavy Bullets Devolver
Paperwork	Origuni Ballot		Origuni occasionally fires 2 shots out of the sides of the character.
Pea Cannon	Old Knight's Helm or Old Knight's Shield	Pea Shooter	Pea Shooter shots become larger, deal more damage, and explode.
Phoenix Up	Phoenix	Any one of the following: Unfinished Gun Copper Ammolet Hot Lead	Summons a Phoenix companion that fires at enemies.
Pistol Machine	Machine Pistol Fortune's Favor		Machine Pistol shots are connected with electricity.
Rock Harder (?)	Face Melter Melted Rock		Causes Face Melter to shoot its bullets in two lines in front of the player instead of a 4-way spread. Same with the amp.
Savior of the Universe	Flash Ray Camera		The Flash Ray gains unlimited piercing, a thicker beam, one bounce, and increased fire rate. The Camera fires 2 laser beams whenever fired.
The Elephant in the Room	Elephant Gun Pig		Elephant Gun becomes an elephant head and shoots elephants instead of bullets.
The Return	Luxin Cannon Pig		Gives Pig a green sprite similar to Cannon, Pig can now shoot fire bats.
Thorn Bath, ooh!	Armor of Thorns Nail Gun		While Nail Gun is held, nails are periodically fired in all directions.
Tutorialized	Old Knight's Helm Old Knight's Shield		A shield orbits the player, blocking enemy bullets.
Whiter Guon Stone	White Guon Stone +1 Bullets		Increases the size of the protective Guon Stone, other effects unknown.
Why's Bullet Crying?	Cold 45 Frost Giant		Attacking a frozen enemy with one of the guns causes a yeti to attack it, dealing high damage.
Queen Ant	Gungeon Ant Heck Blaster		Transforms Gungeon Ant making it fire explosive rounds
Slings and Arrows	Bow + Sling		The Bow and Sling fire faster?
	Abyssal Tentacle Decoy Explosive Decoy		No effect.
	Alpha Bullets Omega Bullets		Reduces reload times by 33%.
	AU Gun Klobbe		Doubles the spread of the Klobbe, decreasing its accuracy.
	A.W.P. Sniper Rifle Wolf		Reduces reload times of the A.W.P. and Sniper Rifle by 30%.
	Badge Full Metal Jacket		Halves the damage the police officer takes.
	Balloon Gun Corsair		Increases movement speed, doubles the damage of the guns, and increases their bullet speed by 20%.
	Bee Hive Honeycomb		Doubles the size of the Bee Hive's bees, increases their damage by 25%, and decreases Bee Hive's rate of fire by 34%.
	Big Iron Witch Pistol		Big Iron fires Witch Pistol shots along with a laser.
	Bullet Shell		No effect.
	Any one of the following: Blunderbuss Crossbow Dueling Pistol Trick Gun	Silver Bullets	Increases the damage of the guns against jammed enemies by 50%. This bonus stacks with the damage from Silver Bullets, for a total of 487.5% damage to jammed enemies.
	Boomerang Utility Belt		Increases the damage of thrown guns by 50%.
	Bow Bomb		Halves the charge time of the Bow and adds a chance for the Bow to fire an extra arrow, similar to the Shadow Bullets effect.
	Brick Breaker or Light Gun	Stuffed Star	Increases the damage of the guns by 25% and the size of their projectiles by 50%.
	BSG Thunderclap		Slightly increases movement speed and increases the shot speed of the guns by 25%.
	Bundle of Wands Owl		Makes Bundle of Wands and Owl shots bounce.
	Charge Shot Jetpack		Decreases the charge time of Charge Shot by 25%.
	Charmed Bow or Shotgun Full of Love	Charming Rounds	All of the Charmed Bow or Shotgun Full of Love's shots are guaranteed to charm enemies.
	Corsair Sense of Direction		Increases Corsair's shot speed by 50%.
	Crown of Guns Coin Crown		Doubles the chance for Coin Crown to spawn money upon completing a room.
	Dart Gun Mega Douser		Increases the damage of the guns by 25%.
	Deck4rd Origuni		Increases the magazine size of both weapons by 50%.
	Demon Head Pitchfork		The Demon Head gains piercing.
	Demon Head Jolter		Reloading the Jolter causes the Demon Head to fire a beam at nearby enemies.
	Dueling Pistol Ballot		Increases the damage of the Dueling Pistol by 25%, and allows its bullets to bounce five times instead of twice.
	Face Melter or Gunzheng	Metronome	Doubles the spread of the guns, decreasing their accuracy.
	Flare Gun Medkit		Reduces the reload time of the Flare Gun by 66% and increases its damage by 50%.
	Freeze Ray Ice Cube		The Freeze Ray gains piercing.
	Frost Giant Heart of Ice		Increases the damage of thrown guns by 180%.
	Gilded Hydra or Old Goldie	Gilded Bullets	Increases the damage of the guns by 25%.
	Gunboots Springheel Boots		Removes the cooldown of Gunboots; every roll will fire bullets.
	Gunknight Helmet Gunknight Armor Gunknight Gauntlet Gunknight Greaves		Cormorant transformation, which removes all reload times and increases curse by 3.
	Any one of the following: Gunslinger's Ashes Shellegun Skull Spitter VertebraeK-47	Zombie Bullets	Doubles the chance for Zombie Bullets to refund missed shots for the guns.
	H4mmer Nail Gun		Increases ammo capacity of both weapons by 50%.
	Heroine Roll Bomb		While Heroine is equipped, increases the damage of Roll Bomb's bombs by 50% and increases the size of the explosions.
	Any one of the following: A.W.P. Bow Hegemony Rifle Hexagun Laser Rifle M1 Sniper Rifle Winchester Rifle	Muscle Relaxant	Increases the damage of the guns by 50%.
	Hegemony Carbine Ruby Bracelet		Hegemony Carbine shots light enemies on fire and bounce.
	Hegemony Rifle Galactic Medal of Valor		Hegemony Rifle bullets are replaced by piercing lasers.
	Huntsman Mahoguny		Increases the damage of the guns by 25%.
	The Judge Badge		Halves the magazine size of the Judge.
	Klobbe Cog of Battle		In addition to its standard bonuses, upon successfully activating an active reload, Cog of Battle multiplies the Klobbe's damage and knockback by 10 and removes all spread.
	Any one of the following: Master Round I Gilded Bullets	Lil' Bomber	Lil' Bomber's bombs become gold and spawn every time they hit an enemy.
	Lower Case r Bracket Key		Increases the damage of Lower Case r by 25%.
	M1 M16 M1911		Increases the damage of the guns by 25%.
	MAC10 Eyepatch		Decreases the reload time of the MAC10 by 33%, increases its magazine size by 50%, and increases its knockback by 50%.
	Makarov Easy Reload Bullets		The Marakov instantly fully reloads after rolling.
	Mailbox Box		Reduces the magazine size of the Mailbox by 50% and reduces its reload time by 33%.
	Microtransaction Gun Mustache		Doubles the Microtransaction Gun's damage.
	Mine Cutter Melted Rock		Increases the Mine Cutter's damage by 25%.
	Mourning Star Cog of Battle		Increases Mourning Star's damage by 25%.
	Pea Shooter Broccoli		Triples the Pea Shooter's damage, doubles the size of the peas, and makes the peas pierce enemies and bounce off of obstacles.
	Plague Pistol Plunger Gas Mask Hazmat Suit		Increases the magazine size of the guns by 50% and increases their spread by 50%, decreasing their accuracy.
	Rad Gun Sunglasses		Decreases the Rad Gun's reload time by 25%.
	Raiden Coil Space Friend		Increases Raiden Coil's max ammo capacity by 25%.
	Railgun Fortune's Favor		Decreases the Railgun's charge time by 10%.
	Rattler Snakemaker		Rattler fires a spread of poison beams instead of bullets.
	SAA Ration Box		Increases coolness by 3 and increases the spread of the SAA by 25%, decreasing its accuracy.
	Shades's Revolver Smiley's Revolver		Doubles maximum ammo and increases magazine size by 50% of both guns.
	Shock Rifle Battery Bullets		Doubles the speed of the Shock Rifle's bullets.
	Shotgrub Monster Blood		Shotgrub bullets gain homing.
	Siren Trident Bionic Leg		Increases the damage of the guns by 25%.
	Tangler Sponge		Increases the knockback of the Tangler by 50%.
	Thompson Sub-Machinegun Laser Sight		The Thompson Sub-Machinegun fires lasers.
	Machine Pistol Laser Sight		Machine Pistol now shoots shock rounds.
	Stinger Laser Sight		Stinger now shoots a bee rocket that homes in on enemys.
	Trashcannon Junk		Increases Trashcannon damage by 25%.
	Trick Gun Blood Brooch		Decreases the reload time of the Trick Gun by 33%.
	Vulcan Cannon Wax Wings		Increases the knockback of the Vulcan Cannon by 50%.
	Wind Up Gun Seven-Leaf Clover		Halves the reload time of the Wind Up Gun.
	Wind Up Gun Oiled Cylinder		The damage and piercing of the Wind Up Gun never decreases.
	+1 Bullets Potion of Gun Friendship		Using the Potion of Gun Frienship summons a Gun.
	Balloon Gun Origuni		The balloon's twisters become faster, the origuni shoots maps and spawns lanterns
	Any one of the following: Gilded Bullets Heck Blaster Crown of Guns Ring of Fire Resistance	Gungeon Ant	Gungeon Ant becomes an Ant queen and shoots rocket ants