Item Combo Strategies

Unofficial combos are combinations of multiple items or guns which work well together, despite not being in-game synergies.

Combos

Items	Description
Super Hot Watch Rad Gun	Allows you to get the active reload easily, making it possible to reach the highest damage level.
Scattershot Remote Bullets	Increases damage by 75% and triples knockback without reducing accuracy.
Remote Bullets Crown of Guns Face Melter Really Special Lute Directional Pad	Creates a wide beam of bullets towards the cursor, very powerful on large enemies.
Eye of the Beholster Easy Reload Bullets Scattershot Backup Gun Double Vision	With just Easy Reload Bullets, allows you to create many Beadie companions quickly. With any of the extra items, allows you to create more Beadies at once, up to 12 at a time.
Magic Lamp Magic Sweet Scattershot	Sweetness and Light allows every shot to spawn a genie, and with Scattershot, every shot can spawn 3 genies.
GuNNER Holey Grail Enraging Photo Cigarettes Antibody	With Holey Grail, taking damage refills GuNNER for the amount of ammo it loses, allowing you to heal the damage back infinitely and also refill ammo on all your guns. Can be combined with Enraging Photo for more damage, Cigarettes for infinite coolness, and/or Antibody for healing more health than damage dealt. Infinite coolness is very good with the Vorpal Gun, which will start to fire only critical shots at 100 coolness.
Bottle Cigarettes	With a Gun Fairy in the Bottle, makes it possible to heal endlessly, so long as you never get fully healed. With Cigarettes, you can constantly take damage while getting infinite coolness. As with the above combo, infinite coolness is very beneficial with the Vorpal Gun.
Table Tech Money Most other Table Tech items	With Table Tech Blanks, flipping a table causes blanks all across the room, which can also activate Ammolet blank effects or Hidden Tech Bees. With Table Tech Heat, multiple pools of fire will be generated throughout the room (especially effective with Hidden Tech Flare). With Table Tech Rocket and/or Table Tech Shotgun, massive firepower is generated (especially with Hidden Tech Big Shotgun for the latter). With Table Tech Stun, all enemies near tables will be stunned.
Crisis Stone Molotov Launcher	Lets you stay invincible during the reload while enemies take fire damage.
Bullet Shell Blank Bullets	Creates many blanks from the mini bullets. The Bullet creates more spread out blanks, while Shell has a greater chance to blank near you.
Meatbun Metronome	Both items grant a damage bonus for taking no damage. Using both is risky, but can result in massive damage boosts. Works well with Balloon Gun or Polaris which both also require taking no damage, and infinite ammo weapons to ensure the Metronome boost doesn't go away.
Makeshift Cannon Magazine Rack Relodestone	Allows you to acquire more ammo for Makeshift Cannon after firing its one shot. Magazine Rack is better for this strategy.
Sling Snowballets	Sling and Snowballets allow for the Snowballets damage boost to take a greater effect when the Sling is ricocheted.
Antibody Green Guon Stone	Taking damage can potentially heal more than the damage you took, allowing you to heal half a heart from taking a hit. The chance of this happening is 10% on every hit, 25% if the hit would have killed you.
Armor of Thorns Blast Helmet Live Ammo	Increases dodge roll damage significantly. Live Ammo and Armor of Thorns is 105 damage, Armor of Thorns and Blast Helmet is 63, Live Ammo and Blast Helmet is 45, and all three is 315 damage. Having all three causes rolls to do more damage than with Ruby Bracelet.
The Scrambler Scattershot	A 65% damage increase from the mini bullets. While this combo works well with any homing bullets, The Scrambler's especially good homing ability make it a good partner to Scattershot.
Flare Gun Irradiated Lead Alpha Bullets Omega Bullets	Causes every shot from Flare Gun to inflict burn and poison at the same time. Works with either Alpha or Omega bullets, it doesn't require both.
Zombie Bullets Roll Bomb Super Space Turtle	Missed Roll Bombs and shots from Super Space Turtle can trigger Zombie Bullets and refill ammo for the player's currently held gun.
Super Hot Watch Bloodied Scarf	Grants you infinite time to decide where to teleport, making the Bloodied Scarf easier to use. The Scarf won't start letting you aim the teleport immediately if time is slowed, so you have to move first before slowing down time.
Scope Super Hot Watch Sniper Rifle A.W.P.	The 360 Yes Scope synergy can be exploited with the Super Hot Watch to create a very-high damage shot. The damage boost from spinning in a circle can be stacked many times while time is slowed.
Gungine Plunger	Both guns receive extra ammo when reloading over poison, so having both allows you to obtain infinite ammo for Gungine.
Book of Chest Anatomy The Exotic	Checking the contents of a chest with The Exotic leaves a great chance for that item to drop from the chest if the chest is broken. Works with any effect that displays a chest's contents, those being Unbelievably Charming, Brave New World, and Detective Mode.
High Kaliber Scattershot	The souls from High Kaliber don't receive a damage reduction from Scattershot, so Scattershot essentially triples the damage of the gun.
Cigarettes Crisis Stone	Using Cigarettes during the Crisis Stone reload invincibility allows you to gain infinite coolness. Does not work with Blasphemy.
Lich's Eye Bullets Glass Cannon	Lich's Eye Bullets grants the Max Pane synergy with Glass Cannon, which makes the gun indestructible. Unlike the normal synergy, which goes away when a Glass Guon Stone is destroyed, the Lich's Eye Bullets synergy can never go away.
Klobbe Cog of Battle	Similar to a synergy, this combination creates a new effect. Cog of Battle's active reload gives a 10x damage boost to Klobbe and reduces all accuracy. This buff only works for however many bullets were fired from the magazine before reloading. An empty mag will buff the entirety of the next one, whereas shooting one bullet and reloading only buffs the first bullet.

Notes

• Feel free to add new entries. Edit in items and a description into the table.