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Combo is an attribute found exclusively in Exit the Gungeon. It is raised by killing the Gundead, and lowered down to a Combo of 1 by being hurt. Using a blank does not reset Combo to 1, however it does reset all progress to the next combo level from the current one.
Your combo affects the following things during gameplay:
The quality of guns that the Sorceress' blessed gun may morph into.