Bosses are strong enemies found at the end of every area in Exit the Gungeon. Defeating a boss allows players to ascend to the next area. Upon being killed, bosses drop a gun or item of random quality, several Hegemony Credits, and two pickups such as hearts or armor. If a boss is killed without the player taking damage, it will also drop a Master Round, increasing the player's max HP.
|His Majesty's Chancellor||Buffammo|
|Bolt Python||Mutread Head||Low Priest|
|The Last Dragun||Gloctopus|